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Designing a whole new world of proteins to address 21st-century problems in biomedicine, energy and technology is all in a day’s work for David Baker. Baker, who is a member of the National Academy of Sciences and the American Academy of Sciences, is leading a team of researchers tackling the problem of protein folding with an online puzzle video game. A world-renowned expert in proteomics, Baker has his research group developing methods to predict and design the three-dimensional structures of proteins.