Making us Better: 2014 Leaders in Health Care Awards

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The 2014 Leaders in Health Care Awards offer evidence of the 
enormous impact of UW Medicine. The entity that owns or operates the University of Washington Medical Center, Harborview Medical Center, Northwest Hospital & Medical Center, Valley Medical Center, UW Neighborhood Clinics, UW Physicians, the UW School of Medicine and Airlift Northwest affects the lives of thousands of people every day.

It’s hardly surprising that 10 of the 25 honorees this year are affiliated in some way with UW Medicine. Still, health care in Washington state remains a remarkably diversified industry, populated by brilliant and heroic people doing noble things for selfless reasons. We salute all of this year’s inspiring honorees for their enthusiastic support of excellent health care.

2014 Leaders in Health Care Finalists

Outstanding Health Care Executive

Winners: Johnese Spisso
Chief Health System Officer, UW Medicine; Vice President Medical Affairs, University of Washington

Joyce Jackson
President and CEO, Northwest Kidney Centers

Silver Award: Claire Trescott, M.D.
Medical Director of Primary Care, Group Health Cooperative

Outstanding Health Care Practitioner

Winner: J. Randall Curtis, M.D.
Director, UW Palliative Care Center of Excellence

Silver Awards: Sean Adelman, M.D.
Orthopedic Surgeon, Group Health Cooperative

Elizabeth Loggers, M.D., Ph.D.
Assistant Member, Fred Hutchinson Cancer Research 
Center; Clinical Assistant Professor, UW School of Medicine

Achievement in Medical Research

Winner: William Catterall, M.D.
Professor and Chair, Department of Pharmacology, UW School of Medicine

Silver Award: Gregory Belenky, M.D.
Director, WSU Sleep and Performance Research Center

Achievement in Biopharmaceuticals

Winner: Kineta
Seattle

Silver Award: Novo Nordisk
Seattle

Achievement in Medical Devices

Winner: Paul Yager, Ph.D.
Professor, UW Department of Bioengineering

Silver Awards: Brian Glaister
President and CEO, Cadence Biomedical

Conrad Smits
SVP Philips Healthcare, CEO Ultrasound Division

Achievement in Community Outreach (Individuals)

Winner: Beti Thompson, Ph.D.
Center for Community Health Promotion, Fred Hutchinson Cancer Research Center

Silver Awards: Julie Gralow, M.D.
Director, Breast Medical Oncology, Seattle Cancer Care 
Alliance; Clinical Research Division Member, Fred 
Hutchinson Cancer Research Cente

Phil Dyer
Senior Vice President, Health Management Services, Kibble & Prentice, a USI Company

Achievement in Community Outreach (Organizations)

Winner: Swedish Community Benefits Program
Swedish Medical Center

Silver Awards: WWAMI Program
UW Medicine

Silence Whooping Cough
Group Health Foundation

Achievement in Wellness Programs

Winner: Faculty & Staff Wellness Program
Western Washington University

Silver Award: Live Well
Miller Nash LLP

Outstanding Global Health Organization

Winner: Grand Challenges in Global Health
Bill & Melinda Gates Foundation

Silver Awards: Department of Global Health
University of Washington

Disaster Relief
World Vision

Lifetime Achievement 

Frederick  Appelbaum, M.D. 

Executive VP and Deputy Director, Fred Hutchinson Cancer Research Center; Executive Director and President, Seattle Cancer Care Alliance

 

Judges for the 2014 Leaders in Health Care Awards

Lisa Cohen, Executive Director, Washington Global Health Alliance 

Leo Greenawalt, Retired President, Washington State Hospital Association

Mary McWilliams, Executive Director, Washington Health Alliance

Joseph Phillips, Ph.D., Dean, Albers School of Business and Economics, Seattle University

Chris Rivera, President and CEO, Washington 
Biotechnology & Biomedical Association

Roger Stark, M.D., Health Care Policy Analyst, Washington Policy Center

Inspired Innovation at Fred Hutch

Inspired Innovation at Fred Hutch

Using the natural defenses of plants and animals, Dr. Jim Olson and his team engineer proteins to attack the most treatment-resistant malignancies.
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On the fifth floor of the Fred Hutchinson Cancer Research Center in Seattle, Dr. Jim Olson and his team are training a robot to process and purify hardy peptides known as knottins, some of which are natural compounds made by plants and animals as diverse as sunflowers and scorpions.

The robot will be capable of churning out work at 50 times the speed of Olson’s best scientists. Olson, a neuro-oncologist at Seattle Children’s Hospital, walks fast, talks fast and carries a big ambition because of the young cancer patients he has known. He once lost an 11-year-old patient named Violet to brain cancer. That experience inspired him to create Project Violet, which raises money for his laboratory’s work at Fred Hutch.

Olson believes knottins can be engineered into therapies that may help thousands of patients to avoid Violet’s fate. He aims to use them not just for brain cancer, but also for Alzheimer’s and other neurodegenerative diseases and maybe even arthritis.  

The reason he sees such a big therapeutic landscape for these compounds has to do with their folded and knotted shape — hence the coinage “knottins.” Their knotted shapes allow them to go places in the human body where other drug therapies can’t easily reach. Olson proudly wears on his upper arm a simplified tattoo shaped liked one of his favorite knottins.

Olson is probably best-known for having invented Tumor Paint, a product that uses the capability of scorpion venom to cross the blood-brain barrier and bind to cancerous tissue. As noted in the September 2012 issue of Seattle Business, he hitched that protein to what he calls a molecular flashlight, a dye that fluoresces when exposed to near-infrared light. 

The clinical version of this paint, BLZ-100 Tumor Paint, won designation from the Food and Drug Administration in 2014 for use on brain tumors. When injected into a patient, the engineered molecule travels to the tumor and makes it glow so surgeons can see its precise boundaries. BLZ-100 is slowly working its way through clinical trials and is being developed by Blaze Bioscience, a private company cofounded by Olson. Recently, Blaze published in the medical journal JAMA a report about research on mice that shows BLZ-100 may eventually be helpful for treating head and neck cancers. 

While working on Tumor Paint, Olson became convinced his team could engineer other knottins for human therapies. Different knottins travel to different parts of the body. Some can cross the blood-brain barrier, making them potentially useful for delivering drugs to the brain, but others have distinct characteristics that allow them to avoid being destroyed by stomach acid and human enzymes. One he has studied in mice travels to the joints, and he imagines hitching a pain reliever to it as an improvement on oral medications for arthritis.

Pharmaceutical companies have known about knottins for years. For a variety of reasons — including the inability to grow them easily in yeast or bacteria, the typical laboratory workhorses — they have been unable to tap their power. Olson discovered he could replicate the proteins by “growing” them inside human kidney cells, a crucial breakthrough. Olson’s team changes the proteins, in some cases giving them payloads to kill cancer cells. Once engineered, they are called optides — an optimized peptide.

Olson’s lab at Fred Hutch has a staff of about 30. He declined to say specifically how much money it spends in a year but described it as similar to a biotech company that might spend $5 million in a year’s time. It occupies about 40,000 square feet. 

The laboratory robot, which cost about $750,000, was custom designed to enable Olson’s lab to generate, process and purify more knottins. An expert scientist might be able to process 10 molecules per week. The robot can produce 500 in the same time.

The idea for the robot came as Olson was talking about his work with a software executive. “He asked me: ‘What is your pain point?’” Olson remembers. Olson, who loves borrowing strategies from software engineering or the tech sciences and applying them to medical research, says automating the process of growing and purifying new compounds struck him as a “pain point” he could target.

That “aha” moment occurred two years ago; the robot arrived earlier this year. By the end of the year, the lab hopes to have a library of 10,000 optides, which will give scientists a far better chance of finding one likely to attach itself to a target of interest, such as a particular lung cancer cell.

Department of Arts and Sciences

Jim Olson likes his team to draw inspiration from art and music. He invited his team to try glassblowing at the Museum of Glass in Tacoma, and their product — some lavender teardrop shapes — hang in the laboratory window in honor of Project Violet.

Two years ago, Olson decided to produce a folk-pop CD — The Violet Sessions — featuring local artists Hey Marseilles, Noah Gundersen, Ben Fisher, Le Wrens, OK Sweetheart, Naomi Wachira and St. Paul De Vence. The crowdfunded project helped raise more than $10,000 for the Olson lab’s research. The CD is still available online and the music can be downloaded via iTunes.

“Creativity is dulled by meetings and piqued by novel experiences,” Olson observes. This appreciation of creativity has been particularly helpful in generating fundraising ideas that are crucial to the success of his laboratory. For example, lab employees came up with the idea of carnival games to help attendees at a recent fundraiser understand the fundamental science taking place. They created an optide bean bag toss with bags of different sizes representing a range of drug candidates. These “drug candidates” had to be tossed into containers of varying sizes that represented the drug targets, such as assorted cancer cells. The event raised more than $500,000.