Breaking Through

| FROM THE PRINT EDITION |
 
 

Scientists have long sought ways to get drugs directly into that final frontier—the human brain. Now, Impel NeuroPharma, a biomedical startup near Swedish Hospital on Capitol Hill, believes its new delivery system will enable drugs to get past the blood-brain barrier (BBB) to previously unreachable regions of the brain.

Founders Michael Hite and John Hoekman met at the University of Washington. After teaming up, they entered and won the university’s 2008 business plan competition. Hite credits the UW with providing “an environment that young companies can be incubated in” and with giving Impel the necessary resources as it expanded.

The drug-delivery system deposits an aerosol spray of a central nervous system drug and in the upper nasal cavity, effectively bypassing the BBB and allowing for easy absorption into the brain. Hite envisions a disposable device that patients can use at home by themselves. Unlike standard nasal pumps that have a wide, high-pressure spray, Impel's device delivers a narrow, low-pressure spray at a focused angle.

Applying the drug through the upper nose eliminates the need to encapsulate or alter the chemical structure of the compound to get past barriers that tend to reduce a drug’s efficacy. By enabling direct contact with the brain, Impel aims to decrease drug exposure throughout the body and drastically lessen side effects.

Impel’s technology could treat diseases like AIDS and pesticide overdoses more effectively. Presently, even the best drugs cannot eliminate elements of AIDS in the brain reservoir, and overdose victims must go to emergency rooms for treatment. Impel’s device would enable chemicals to actually reach the affected portions of the brain, and also allow customers to treat pesticide overdoses at home.

Hite says Impel will begin the first human study of its technology later this year. The trial aims to treat pain and should provide the company with human data in early 2012. If successful, Impel could revolutionize how effectively drugs treat medical conditions.

Sponsored

Smart Glasses Improving Workflow for HVAC Projects

Smart Glasses Improving Workflow for HVAC Projects

Wearable technology increases productivity for HVAC technicians
 
 

Sponsored by MacDonald-Miller

XOEye technologies created a smart glasses tool, built specifically for field technicians to capture real-time documentation. When MacDonald-Miller heard about the new wearable technology platform, they saw it as an opportunity to be the first mechanical contractor in the Pacific Northwest to implement these smart glasses into their services.

We interviewed MacDonald-Miller’s Chief Information Officer, Bradd Busick, to hear first-hand how this new technology will be integrated into services and how it will streamline HVAC projects.

What are the capabilities of the smart glasses? 

The smart glasses, MacLens, capture and stream high fidelity audio and visual content, enabling first-person point-of-view (POV). MacLens includes a camera, earpiece, and microphone — all built into a single headset, capturing real-time documentation of equipment, work performed, and recommendations being made. 

How does it work for technicians?

Once service techs arrive onsite, they put their MacLens glasses on to create an intro video communicating where they are, a brief diagnosis or repair identification, and a summary recap for the customer. After the site visit is complete, the tech then uploads the content to the call summary report on the customer portal, where customers can access it at their convenience.

What is the benefit for the end-user?

Building owners and property managers have to trust their maintenance provider is actually doing the work they claim. Most building owners will never see the work being done on their properties, but they will receive a list of recommendations for changes and a bill. It’s a relationship built on trust. MacLens adds a level of transparency and customer experience where we are able to show in real-time what is happening on roofs and in mechanical rooms. MacLens embeds audio and video content into each summary report, providing customers with the peace of mind that comes with unbridled transparency.

What is the vision behind this technology roll-out?

The goal is to enhance the customer connection to the services provided and also enable technicians to connect with each other. There are incredible operational efficiencies that enable mobility and collaboration through telepresence and increased accountability.

How will they affect the next wave of HVAC technicians?

Not only will MacLens increase workflow productivity, but it also offers training opportunities and safety benefits without adding any additional work to service technicians. This is a major educational advantage. Now expert journeyman can train apprentices simply by walking through their daily tasks, recording those sessions and sharing them in our learning management system — it’s the next evolution of training!

See MacLens in action here.

MacDonald-Miller Facility Solutions is a full-service, design-build, mechanical contractor in the Pacific Northwest. Learn more about MacDonald-Miller’s recent projects.